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As discussed inChapter 3, the desired net outcome of the biotransformationprocess is generally to alter the chemical in such a way thatit is (i) no longer biologically active within the body and (ii)more polar and water-soluble and, consequently, more easilyexcreted from the body. The connecting stalk appears as the constrictedregion ofthe cell that joins the inner to the outer segment.In this region, a thin, tapering process called the calycealprocess extends from the distal end ofthe inner segmentto surround the proximal portion of the outer segment(see Fig

The connecting stalk appears as the constrictedregion ofthe cell that joins the inner to the outer segment.In this region, a thin, tapering process called the calycealprocess extends from the distal end ofthe inner segmentto surround the proximal portion of the outer segment(see Fig. Patients should be started at high doses(60–80 mg) in severe cases, but lower doses, graduallyincreasing over time, can be employed in particularclinical circumstances

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Failure of incretinshas been implicated in the pathogenesis of celldysfunction of type 2 DM, particularly progressionof the disease. Thrombolytics are indicated when the patient has chest pain for< 12 hours and has ST segment elevation in 2 or more leads

Thrombolytics are indicated when the patient has chest pain for< 12 hours and has ST segment elevation in 2 or more leads.